Biohacking Knowledge Base — Master Index
System Architecture
Central Map of Content (MOC) organizing biohacking research, mechanisms, diagnostics, and interventions across four primary silos.
graph LR Index["00 - Biohacking Index"] --> S1["01 - Foundations"] Index --> S2["02 - Compounds & Molecules"] Index --> S3["03 - Diagnostics & Quantified Self"] Index --> S4["04 - Longevity & Environment"] Index --> S5["05 - Runbooks & Field Protocols"] S1 --> S1A["Sleep & Circadian"] S1 --> S1B["Nutrition & Metabolic"] S1 --> S1C["Exercise & Performance"] S1 --> S1D["Nervous System & HRV"] S2 --> S2A["Supplements & Micros"] S2 --> S2B["Nootropics & Neurochemistry"] S2 --> S2C["Peptides & Bioregulators"] S2 --> S2D["Pharmacology"] S3 --> S3A["Bloodwork & Biomarkers"] S3 --> S3B["Genetics & Epigenetics"] S3 --> S3C["Gut & Microbiome"] S3 --> S3D["Wearables & Biometrics"] S4 --> S4A["Cellular Senescence & NAD+"] S4 --> S4B["Light & Photobiomodulation"] S4 --> S4C["Thermal Hormesis"] S4 --> S4D["Environment & Toxin Mitigation"] S5 --> S5A["Runbook 01: Somatic & Myofascial"] S5 --> S5B["Runbook 02: Breath & Dive Reflex"] S5 --> S5C["Runbook 03: Thermal ANS Calibration"] Index --> S97["97 - Sourcing & Supply Chain"] Index --> R98["98 - References"] S97 -.->|"Pricing & Gear"| S1 & S2 & S3 & S4 R98 -.->|"Mirrors 01-05"| S1 & S2 & S3 & S4 & S5
Core Silos
1. 01 — Foundations
Baseline physiological levers that govern 80%+ of healthspan and performance output.
- Sleep & Circadian Biology: Sleep Architecture · Circadian Entrainment & Zeitgebers · Chronotypes & Melatonin Dynamics · Sleep Environment & Hygiene
- Nutrition & Metabolic Health: Metabolic Flexibility & Insulin Sensitivity · Time-Restricted Feeding & Fasting · Mitochondrial Energetics · Hydration & Electrolytes
- Exercise & Physical Performance: Zone 2 & VO2 Max · Resistance Training & Hypertrophy · Recovery & Supercompensation · Mobility & Fascia
- Nervous System & Autonomic Regulation: Vagal Tone & HRV Regulation · Breathwork Protocols · HPA Axis & Cortisol Modulation · NSDR & Neuroplasticity
2. 02 — Compounds & Molecules
Exogenous and endogenous molecules targeting specific biochemical pathways, receptors, and signaling cascades.
- Supplements & Micronutrients: Magnesium Forms & Bioavailability · Vitamin D3, K2 & Calcium Homeostasis · Omega-3 & Lipid Membrane Health · Methylation & B-Complex · Creatine & Phosphocreatine System
- Nootropics & Neurochemistry: Cholinergics (Alpha-GPC, Citicoline) · Racetams & AMPAkines · Dopaminergics & Catecholamines · Adaptogens · Neurotrophins (BDNF, NGF, Lion’s Mane) · GABAergics & Anxiolytics
- Peptides & Bioregulators: Tissue Repair Peptides (BPC-157, TB-500, GHK-Cu) · GH Secretagogues (Ipamorelin, CJC-1295, Tesamorelin) · Cognitive & Neurogenic Peptides (Semax, Selank, Dihexa) · Mitochondrial & Metabolic Peptides (MOTS-c, SS-31, GLP-1) · Khavinson Bioregulators (Epitalon, Pinealon) · Immune & Thymic Peptides (Thymosin Alpha-1, LL-37)
- Longevity & Repurposed Pharmacology: mTOR & Autophagy Modulators (Rapamycin) · AMPK & Glycemic Agents (Metformin, Berberine, Acarbose) · PDE5 Inhibitors & Endothelial Function · Methylene Blue & Electron Transport Chain
3. 03 — Diagnostics & Quantified Self
Objective measurement of biomarkers, multi-omics, and continuous physiological telemetry.
- Bloodwork & Systemic Biomarkers: Cardiometabolic Panel (ApoB, Lp(a), HbA1c, Fasting Insulin) · Inflammation & Oxidative Stress (hs-CRP, Homocysteine, GGT) · Endocrine & Hormone Panel · Thyroid Panel · Hematology, Iron & Nutrient Panel · Hepatic & Renal Function (Cystatin C, eGFR)
- Genetics, Epigenetics & Multi-Omics: Methylation & Detox SNPs (MTHFR, COMT, GST) · Lipid & Longevity Variants (APOE, FOXO3) · Neurotransmitter & Circadian Variants · Epigenetic Clocks (DunedinPACE, Horvath, GrimAge)
- Gut Microbiome & GI Diagnostics: Microbiome Diversity & Keystone Species · Intestinal Permeability & Zonulin · SCFAs (Butyrate, Propionate, Acetate) · SIBO, Dysbiosis & Organic Acids Test (OAT)
- Wearables & Continuous Biometrics: Continuous Glucose Monitoring (CGM) & Glycemic Variability · HRV, RHR & Autonomic Readiness · Sleep Staging & Actigraphy · Body Composition (DEXA, Visceral Fat) · Blood Pressure & Pulse Wave Velocity
4. 04 — Longevity & Environment
Hallmarks of aging interventions, hormetic stressors, biophysics, and environmental toxicology.
- Cellular Health, NAD+ & Hallmarks of Aging: NAD+ Salvage Pathway (NMN, NR, CD38 Inhibition) · Cellular Senescence & Senolytics (Fisetin, Quercetin, Dasatinib) · Autophagy & Mitophagy (Spermidine, Urolithin A) · Mitochondrial Biogenesis & Uncoupling · Glycation & AGEs Inhibition (Carnosine, Benfotiamine)
- Photobiomodulation & Light Environment: Red & Near-Infrared Light Therapy (660nm, 850nm) · Circadian Lighting & Melanopic Lux · UV Exposure, Nitric Oxide & Photobiology · Blue Light Mitigation & Retinal Health
- Thermal Hormesis (Heat & Cold): Sauna Protocols & Heat Shock Proteins · Cold Plunge, Norepinephrine & Brown Adipose Tissue · Contrast Therapy & Vascular Conditioning
- Environment & Toxin Mitigation: Water Filtration, Remineralization & Hydrogen · Indoor Air Quality (PM2.5, CO2, VOCs, HEPA) · Heavy Metals, Microplastics & Endocrine Disruptors (PFAS, BPA) · Detoxification Pathways (Phase I-III, Glutathione, Binders)
5. 05 — Runbooks & Field Protocols (Operational SOPs)
Situational step-by-step execution playbooks chaining mechanisms across Silos 01–04.
- Autonomic Nervous System Regulation: Runbook 01 - Interoceptive Somatic Scan & Myofascial Down-Regulation · Runbook 02 - Acute Brainstem & Dive Reflex Reset (Breath + Trigeminal Cold) · Runbook 03 - Hormetic ANS Range Calibration (Progressive Cold & Heat Boundaries)
97. 97 — Sourcing, Pricing & Hardware Upgrades (Mirrored 01–04)
Vetted vendors, COA standards, recurrent consumable run-rates, and hardware upgrade paths refreshed by [[Price Refresh Agent Task|sourcing-price-refresher]].
- 01 - Foundations Sourcing MOC · 02 - Compounds & Molecules Sourcing MOC · 03 - Diagnostics & Quantified Self Sourcing MOC · 04 - Longevity & Environment Sourcing MOC
98. 98 — Scientific References (Mirrored 01–04)
Dedicated peer-reviewed literature dossiers mirroring every silo and topic note.
- 01 - Foundations References MOC · 02 - Compounds & Molecules References MOC · 03 - Diagnostics & Quantified Self References MOC · 04 - Longevity & Environment References MOC
Databases & Views (Obsidian Bases)
Silo Atlas
| Hub Note | Silo | Category | Description |
|---|---|---|---|
| 01 - Foundations MOC | 01 - Foundations | Core Physiology | Sleep & circadian biology, nutrition & metabolic health, exercise physiology, and autonomic nervous system regulation. |
| 02 - Compounds & Molecules MOC | 02 - Compounds & Molecules | Exogenous & Endogenous Interventions | Supplements, micronutrients, nootropics, peptides, bioregulators, and repurposed longevity pharmacology. |
| 03 - Diagnostics & Quantified Self MOC | 03 - Diagnostics & Quantified Self | Biomarkers & Telemetry | Systemic bloodwork panels, multi-omics (genetics/epigenetics), microbiome analysis, and continuous wearable telemetry. |
| 04 - Longevity & Environment MOC | 04 - Longevity & Environment | Geroscience & Biophysics | Hallmarks of aging, NAD+ & senolytics, photobiomodulation, thermal hormesis, and environmental toxin mitigation. |
| 05 - Runbooks & Field Protocols MOC | 05 - Runbooks & Field Protocols | Autonomic Nervous System SOPs | Operational step-by-step field runbooks chaining interoceptive somatic scanning, respiratory brainstem resets, trigeminal dive reflex, and progressive thermal boundary calibration. |
| 01 - Foundations Sourcing MOC | 97 - Sourcing & Supply Chain | Sleep, Metabolic, Exercise & ANS Gear/Consumables | Sourcing, pricing, and hardware upgrade roadmap for 01 - Foundations. |
| 02 - Compounds & Molecules Sourcing MOC | 97 - Sourcing & Supply Chain | Nutraceuticals, Nootropics, Peptides & Pharmacology Procurement | Vendor vetting, COA verification standards, unit pricing, and reconstitution supplies for 02 - Compounds & Molecules. |
| 03 - Diagnostics & Quantified Self Sourcing MOC | 97 - Sourcing & Supply Chain | DTC Bloodwork, Multi-Omic Kits, CGM Sensors & Biometric Wearables | Pricing and provider comparison for bloodwork panels, multi-omic test kits, CGM consumables, and wearable hardware. |
| 04 - Longevity & Environment Sourcing MOC | 97 - Sourcing & Supply Chain | Geroscience Compounds, PBM, Thermal Hardware & Air/Water Filtration | Sourcing, filter replacement cadences, and hardware tiers for 04 - Longevity & Environment. |
| 97 - Sourcing & Supply Chain MOC | 97 - Sourcing & Supply Chain | Procurement, Pricing, QA & Hardware Upgrades | Mirrored sourcing, vendor QA/COA standards, recurrent consumable pricing, and hardware upgrade matrix across silos 01–04. |
| Price Refresh Agent Task | 97 - Sourcing & Supply Chain | Automation & Task Specification | Reusable task specification and trigger instructions for the predefined sourcing-price-refresher subagent. |
| 01 - Foundations References MOC | 98 - References | Sleep, Metabolic, Exercise & Nervous System Literature | Mirrored reference hub for 01 - Foundations topics. |
| 02 - Compounds & Molecules References MOC | 98 - References | Supplements, Nootropics, Peptides & Pharmacology Literature | Mirrored reference hub for 02 - Compounds & Molecules topics. |
| 03 - Diagnostics & Quantified Self References MOC | 98 - References | Biomarkers, Multi-Omics, Microbiome & Wearables Literature | Mirrored reference hub for 03 - Diagnostics & Quantified Self topics. |
| 04 - Longevity & Environment References MOC | 98 - References | Geroscience, Photobiomodulation, Thermal & Toxicology Literature | Mirrored reference hub for 04 - Longevity & Environment topics. |
| 05 - Runbooks & Field Protocols References MOC | 98 - References | Autonomic Regulation, Dive Reflex, Interoception & Thermal Adaptation Literature | Mirrored peer-reviewed scientific literature backing 05 - Runbooks & Field Protocols. |
| 98 - References MOC | 98 - References | Scientific Literature & Citations | Mirrored scientific literature index (01–04) containing peer-reviewed studies, DOIs/PMIDs, open-access identifiers, and evidence grading. |
| Evidence Verification & Epistemic Hygiene Guide | 98 - References | Scientific Verification & Audit Protocol | Automated NCBI Entrez PubMed API verification audit (309/309 verified PMIDs), direct-access source links, and evidence tier grading protocol. |
| Imported Readings & Synopses MOC | 98 - References | Imported Papers & Monographs | Index of scientific papers, PDFs, and personal reference readings ingested from d:\AI\biohacking\import and mapped across Silos 01–04. |
Compounds & Interventions Tracker
| Compound / Class | Category | Mechanism | Standard Dose | Evidence Tier |
|---|---|---|---|---|
| Sleep Supplementation & Pharmacology | Sleep & Circadian Biology | Synergistic modulation of GABA-A allosteric sites, NMDA receptor blockade, SCN NMDA-mediated peripheral vasodilation, and dual orexin receptor (OX1R/OX2R) antagonism to promote sleep initiation and preserve N3/REM architecture. | Magnesium L-Threonate (144 mg elemental) or Bisglycinate (200-400 mg); Glycine (3 g); Apigenin (50 mg); L-Theanine (100-200 mg); Myo-Inositol (900 mg) | 🟢 Tier 1 |
| AMPK & Glycemic Agents (Metformin, Berberine, Acarbose) | Longevity & Repurposed Pharmacology | Mild mitochondrial Complex I & mGPDH inhibition elevating AMP:ATP ratios to activate AMPK (Metformin/Berberine), brush-border alpha-glucosidase blockade (Acarbose), and renal SGLT2 glucosuria | Metformin ER 500–1,500 mg/day; Dihydroberberine 100–200 mg 2x/day (or Berberine HCl 500 mg 2–3x/day); Acarbose 25–50 mg with first bite of starch meals; Empagliflozin 10 mg/day | 🟢 Tier 1 |
| Adaptogens | Nootropics & Neurochemistry | HPA-axis cortisol modulation, Heat Shock Protein 70 (Hsp70) & Neuropeptide Y (NPY) chaperone induction, and AMPK/mitochondrial stress-response hormesis | Rhodiola rosea 200–400 mg/day; Ashwagandha 300–600 mg/day; Panax ginseng 200–400 mg/day; Cordyceps militaris 1,000–3,000 mg/day | 🟢 Tier 1 |
| Amino Acids & Precursors | Foundational Supplements & Micronutrients | Intracellular glutathione restoration (GlyNAC), mitochondrial tRNA taurine-modification, urea/eNOS nitric oxide cycling (L-Citrulline), and carnosine H+ buffering | Taurine 2–6 g/day; Glycine 3–10 g/day; NAC 600–2,400 mg/day; L-Citrulline 4–8 g/day; Beta-Alanine 3.2–6.4 g/day | 🟢 Tier 1 |
| Cholinergics (Alpha-GPC, Citicoline) | Nootropics & Neurochemistry | Blood-brain barrier choline and cytidine/uridine delivery driving Choline Acetyltransferase (ChAT) acetylcholine synthesis and Kennedy Pathway phospholipid repair | Alpha-GPC 300–600 mg/day; Citicoline (CDP-Choline) 250–500 mg/day; ALCAR 500–1,500 mg/day | 🟢 Tier 1 |
| Cognitive & Neurogenic Peptides (Semax, Selank, Dihexa) | Peptides & Bioregulators | Intranasal olfactory-trigeminal delivery driving hippocampal BDNF/TrkB upregulation (Semax), enkephalinase inhibition & GABAA modulation (Selank), and HGF/c-Met synaptogenesis (Dihexa) | Semax (or NA-Semax-Amidate) 200–600 mcg/day intranasal; Selank (or NA-Selank-Amidate) 250–750 mcg/day intranasal; Dihexa 2–5 mg transdermal/oral (1–2x/week); P21 500–1,000 mcg/day | 🟡 Tier 2 |
| Creatine & Phosphocreatine System | Foundational Supplements & Micronutrients | Reversible creatine kinase (CK) phosphagen buffering of ADP to ATP, mitochondrial creatine shuttle optimization, and GAMT methylation sparing | 5 g/day Creatine Monohydrate (myocyte saturation); 10–20 g/day for cerebral saturation or acute sleep deprivation | 🟢 Tier 1 |
| Dopaminergics & Catecholamines | Nootropics & Neurochemistry | Rate-limiting Tyrosine Hydroxylase (TH) substrate saturation and epigenetic upregulation (Bromantane) driving prefrontal and striatal dopamine/norepinephrine synthesis | L-Tyrosine 500–2,000 mg; N-Acetyl-L-Tyrosine (NALT) 350–700 mg; Bromantane 25–100 mg/day; Mucuna Pruriens (L-DOPA) 50–150 mg (acute only) | 🟢 Tier 1 |
| GABAergics & Anxiolytics | Nootropics & Neurochemistry | Allosteric GABAA modulation, Glutamate Decarboxylase (GAD) upregulation, GABA Transaminase (GABA-T) inhibition, and TSPO neurosteroid synthesis | L-Theanine 100–400 mg; Lemon Balm (Cyracos) 300–600 mg; Magnolia Bark 200–400 mg; Emoxypine (Mexidol) 125–250 mg; Apigenin 50 mg | 🟢 Tier 1 |
| GH Secretagogues (Ipamorelin, CJC-1295, Tesamorelin) | Peptides & Bioregulators | Dual activation of pituitary GHRH receptors (cAMP/PKA) and Ghrelin/GHS-R1a receptors (PLC/IP3/Ca2+) to amplify endogenous pulsatile Growth Hormone and hepatic IGF-1 secretion | Ipamorelin 100–300 mcg + CJC-1295 (No DAC / Mod GRF 1-29) 100–200 mcg SubQ; Tesamorelin 1.0–2.0 mg/day SubQ | 🟢 Tier 1 |
| Immune & Thymic Peptides (Thymosin Alpha-1, LL-37) | Peptides & Bioregulators | Toll-Like Receptor (TLR2/4/9) dendritic cell priming & CD4+/CD8+/Treg immunosenescence reversal (Thymosin Alpha-1) alongside cationic amphipathic bacterial/biofilm membrane disruption (LL-37) | Thymosin Alpha-1 1.5–1.6 mg SubQ 2x/week (longevity/prophylaxis) or 1.6 mg/day for 5–7 days (acute viral); LL-37 100–125 mcg/day SubQ for 2–4 weeks | 🟢 Tier 1 |
| Khavinson Bioregulators (Epitalon, Pinealon) | Peptides & Bioregulators | Sequence-specific DNA minor-groove binding and histone H1/H4 epigenetic decondensation driving hTERT telomerase expression and pineal AANAT melatonin synthesis | Epitalon 1–5 mg/day SubQ for 10–20 days (or 10 mg every 3 days for 5 doses); Pinealon 1–2 mg/day SubQ/intranasal or 10–20 mg/day oral for 10–20 days | 🟡 Tier 2 |
| Magnesium Forms & Bioavailability | Foundational Supplements & Micronutrients | Obligate divalent cation cofactor for >600 enzymatic reactions, ATP-Mg2+ chelation, voltage-dependent NMDA receptor blockade, and L-type Ca2+ channel antagonism | 300–500 mg/day elemental Mg (144–200 mg elemental from 2,000 mg Mg L-Threonate) | 🟢 Tier 1 |
| Methylation & B-Complex | Foundational Supplements & Micronutrients | One-carbon metabolism cofactor supply for S-Adenosylmethionine (SAMe) synthesis, homocysteine remethylation (MTHFR/MTR/BHMT), and transsulfuration (CBS) | 400–800 mcg L-5-MTHF + 500–1,000 mcg Methyl/Adenosyl/Hydroxocobalamin + 10–25 mg P5P + 10–25 mg Riboflavin-5-Phosphate + 1,000–2,000 mg TMG | 🟢 Tier 1 |
| Methylene Blue & Electron Transport Chain | Longevity & Repurposed Pharmacology | Reversible redox cycling (MB ←> Leucomethylene Blue) acting as an alternative mitochondrial electron carrier bypassing Complex I/III to Cytochrome c (Complex IV) and upregulating Cytochrome c Oxidase | Low-dose hormetic window: 0.5–1.0 mg/kg/day (typically 5–25 mg/day for routine neuro-bioenergetics; max 0.5–2.0 mg/kg in clinical fMRI memory studies) | 🟢 Tier 1 |
| Mitochondrial & Metabolic Peptides (MOTS-c, SS-31, GLP-1) | Peptides & Bioregulators | Inner mitochondrial membrane cardiolipin stabilization (SS-31), folate-AICAR-AMPK nuclear retro-signaling (MOTS-c), and incretin GLP-1/GIP/Glucagon receptor agonism (Retatrutide/Tirzepatide) | MOTS-c 5 mg SubQ 2–3x/week; SS-31 (Elamipretide) 2–5 mg/day SubQ; Semaglutide 0.25–2.4 mg/week; Tirzepatide 2.5–15 mg/week; Retatrutide 1–8 mg/week | 🟢 Tier 1 |
| Neurotrophins (BDNF, NGF, Lion’s Mane) | Nootropics & Neurochemistry | Induction of Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF) synthesis alongside direct Tropomyosin Receptor Kinase B (TrkB) agonism | Lion’s Mane (fruiting body + erinacine mycelium) 1,000–3,000 mg/day; 7,8-DHF 15–30 mg/day (4’-DMA-7,8-DHF 8–10 mg); Bacopa monnieri 300 mg/day; Polygala tenuifolia 100–300 mg/day | 🟢 Tier 1 |
| Omega-3 & Lipid Membrane Health | Foundational Supplements & Micronutrients | Cell membrane phospholipid incorporation, competitive COX/LOX eicosanoid shifting, PPAR-alpha/gamma activation, and synthesis of Specialized Pro-resolving Mediators (SPMs) | 2,000–4,000 mg/day combined EPA + DHA (targeting an RBC Omega-3 Index of 8–12%) | 🟢 Tier 1 |
| PDE5 Inhibitors & Endothelial Function | Longevity & Repurposed Pharmacology | Selective inhibition of Phosphodiesterase Type 5 (PDE5), preventing cyclic GMP (cGMP) hydrolysis to amplify endothelial nitric oxide (eNOS-NO-sGC-PKG) microvascular perfusion | Tadalafil 2.5–5.0 mg/day (microvascular longevity & endothelial protocol); Sildenafil 20–50 mg as needed | 🟢 Tier 1 |
| Racetams & AMPAkines | Nootropics & Neurochemistry | Positive allosteric modulation of AMPA glutamate receptors, neuronal phospholipid membrane fluidization, and hippocampal high-affinity choline uptake (HACU) acceleration | Piracetam 2,400–4,800 mg/day; Aniracetam 750–1,500 mg/day; Oxiracetam 750–1,500 mg/day; Phenylpiracetam 100–200 mg; Noopept 10–30 mg/day | 🟢 Tier 1 |
| Tissue Repair Peptides (BPC-157, TB-500, GHK-Cu) | Peptides & Bioregulators | VEGFR2/eNOS angiogenesis, Focal Adhesion Kinase (FAK-paxillin) tendon fibroblast migration, G-actin sequestration, and TGF-beta/epigenetic ECM remodeling | BPC-157 250–500 mcg 1–2x/day; TB-500 (Thymosin Beta-4) 2.0–2.5 mg 2x/week; GHK-Cu 1–2 mg/day SubQ or 1–2% topical; KPV 250–500 mcg/day | 🟡 Tier 2 |
| Vitamin D3, K2 & Calcium Homeostasis | Foundational Supplements & Micronutrients | Nuclear Vitamin D Receptor (VDR) transcriptional activation paired with Vitamin K2-dependent gamma-carboxylation of Osteocalcin and Matrix Gla Protein (MGP) | 2,000–5,000 IU/day (50–125 mcg) Vitamin D3 + 100–200 mcg/day Vitamin K2 (MK-7) or 1.5–45 mg/day (MK-4) | 🟢 Tier 1 |
| mTOR & Autophagy Modulators (Rapamycin) | Longevity & Repurposed Pharmacology | Allosteric FKBP12-rapamycin complex binding to the FRB domain of mTORC1, suppressing S6K1/4E-BP1 hyperfunction and disinhibiting ULK1/TFEB macroautophagy | Sirolimus (Rapamycin) 3–6 mg pulsed once weekly (or 8–12 mg once every 10–14 days); Everolimus 5 mg once weekly | 🟢 Tier 1 |
| Autophagy & Mitophagy (Spermidine, Urolithin A) | Cellular Health, NAD+ & Hallmarks of Aging | Spermidine inhibits EP300 acetyltransferase and hypusinates eIF5A to translate TFEB/ATG3 (macroautophagy), while Urolithin A stabilizes PINK1/Parkin to selectively ubiquitylate and clear depolarized mitochondria (mitophagy). | Urolithin A 500–1,000 mg/day; Spermidine 6–15 mg/day (wheat germ extract or pure trihydrochloride); Trehalose 5–15 g/day | 🟢 Tier 1 |
| Cellular Senescence & Senolytics (Fisetin, Quercetin, Dasatinib) | Cellular Health, NAD+ & Hallmarks of Aging | Transient ‘hit-and-run’ inhibition of Senescent Cell Anti-Apoptotic Pathways (SCAPs: PI3K/AKT, BCL-2/BCL-xL, Src tyrosine kinases, p53/p21) to induce selective apoptosis of p16INK4a+ senescent cells and suppress SASP. | Fisetin 20 mg/kg/day (or 1,000–1,500 mg liposomal) for 2–3 consecutive days every 1–3 months; Quercetin Phytosome 500–1,000 mg/day during pulse | 🟢 Tier 1 |
| Glycation & AGEs Inhibition (Carnosine, Benfotiamine) | Cellular Health, NAD+ & Hallmarks of Aging | Benfotiamine activates transketolase to shunt glycolytic triosephosphates away from methylglyoxal formation, while L-Carnosine scavenges reactive dicarbonyls (MGO/GO) and blocks RAGE-NF-kB signaling. | L-Carnosine 1,000–1,500 mg/day (or Beta-Alanine 3.2 g/day) + Benfotiamine 300–600 mg/day + Pyridoxamine/P5P 50 mg/day | 🟢 Tier 1 |
| NAD+ Salvage Pathway (NMN, NR, CD38 Inhibition) | Cellular Health, NAD+ & Hallmarks of Aging | Upregulation of intracellular NAD+ biosynthesis via NAMPT/NRK salvage enzymes paired with CD38 ecto-NADase inhibition to fuel sirtuins (SIRT1-7) and PARPs. | NMN 500–1,000 mg/day or NR 500–1,000 mg/day + Apigenin 50–100 mg/day + TMG 500–1,000 mg/day | 🟢 Tier 1 |
Sourcing, Consumables & Hardware Tracker (Finland & EU — EUR €)
| Dossier | Silo | Market Tier | Price Range (€) | Est. €/Mo | Reorder Cadence |
|---|---|---|---|---|---|
| Exercise, VO2 Max & Recovery Hardware - Sourcing | 01 - Foundations | Tier 1: Finland · Tier 2: EU Single Market | €29,90–€399,00 (Hardware) · €59,00–€79,00 (25x Lactate Strips) | €16 | 3–5 years (Hardware) · 12–18 months (Polar Pro Strap) · Quarterly (Lactate Strips) |
| Metabolic & Electrolyte Consumables - Sourcing | 01 - Foundations | Tier 1: Finland · Tier 2: EU Single Market | €12,90–€49,90 / unit | €68 | 30–60 days (Electrolytes, Whey & EVOO) · 6–12 months (Bulk Salts) |
| Nervous System & Vagal Hardware - Sourcing | 01 - Foundations | Tier 1: Finland · Tier 2: EU Single Market | €49,00–€699,00 (Hardware) | €5 | 3–5 years (Hardware) · 6–12 months (Electrode Gel & Ear Clips) |
| Sleep Environment & Thermal Hardware - Sourcing | 01 - Foundations | Tier 1: Finland · Tier 2: EU Single Market | €4,50–€39,00 (Consumables) · €219–€2.699 (Hardware) | €25 | 3–5 years (Thermal Hardware) · 30–90 days (3M Micropore Tape, Nasal Dilators & H2O2) |
| Foundational Supplements & Micronutrients - Sourcing | 02 - Compounds & Molecules | Tier 1: Finland · Tier 2: EU Single Market | €13,50–€44,90 / unit | €85 | 30–90 days |
| Longevity & Repurposed Pharmacology - Sourcing | 02 - Compounds & Molecules | Tier 1: Finland (Apteekki / Kanta Rx) · Tier 2: EU Single Market (OTC Methylene Blue & Berberine) | €4,50–€68,00 / package | €45 | 90 days (Kanta e-Prescription Pharmacy Refills) |
| Nootropics & Neurochemicals - Sourcing | 02 - Compounds & Molecules | Tier 1: Finland · Tier 2: EU Single Market | €14,90–€49,90 / unit | €60 | 45–90 days (Cycled Interventions) |
| Peptides, Bioregulators & Reconstitution Supplies - Sourcing | 02 - Compounds & Molecules | Tier 1: Finland (Medical Supplies) · Tier 2: EU Single Market (Janoshik-Tested) | €32,00–€95,00 / vial (Peptides) · €4,50–€24,90 (Sterile Supplies) | €120 | 8–12 week cycles (Peptides) · 28 days (Opened BAC Water) · 90 days (Syringes & Filters) |
| Bloodwork & Systemic Lab Panels - Sourcing | 03 - Diagnostics & Quantified Self | Tier 1: Finland Domestic (SYNLAB Suomi / Puhti / Nightingale) | €68,00–€249,00 / panel (€8,00–€85,40 / individual marker) | €35 | Every 6 months (Semi-Annual Longevity Panel) |
| Genetics, Epigenetics & Multi-Omic Kits - Sourcing | 03 - Diagnostics & Quantified Self | Tier 1: Finland (Evogenom / SYNLAB) · Tier 2: EU Single Market (Dante / TellMeGen / GlycanAge / MoleQlar) | €149,00–€499,00 / kit | €30 | Once in Lifetime (30x WGS / SNPs) · Every 6–12 months (DunedinPACE / GlycanAge) |
| Gut Microbiome & GI Diagnostic Kits - Sourcing | 03 - Diagnostics & Quantified Self | Tier 1: Finland (SYNLAB / GutGuide / Nordic Labs) · Tier 2: EU Single Market (BiomeOne / Biomes DE) | €54,00–€449,00 / test | €25 | Every 6–12 months (or Post-Protocol Verification) |
| Wearables & Continuous Telemetry Hardware - Sourcing | 03 - Diagnostics & Quantified Self | Tier 1: Finland Domestic (Oura / Polar / Suunto / Libre 3 / DEXA) | €65,00–€79,00 / 14–15d CGM Sensor · €89–€399 (Wearables) · €79–€145 (DEXA Scan) | €45 | 14–15 days per CGM Sensor (Quarterly Audit) · Semi-Annual (DEXA) · 3–5 years (Wearables) |
| Air, Water & Toxin Mitigation Supplies - Sourcing | 04 - Longevity & Environment | Tier 1: Finland Domestic (Aqva.fi / Verkkokauppa.com / STUK Radon) · Tier 2: EU Single Market | €19,90–€89,00 (Filters & Binders) · €149–€699 (Hardware) | €32 | 6–12 months (AQVA Carbon/HEPA Filters) · 24 months (RO Membrane) |
| NAD+ Precursors, Senolytics & Autophagy Compounds - Sourcing | 04 - Longevity & Environment | Tier 1: Finland (Puhdas+ / Biomed / Sinunapteekki) · Tier 2: EU Single Market (MoleQlar / Purovitalis / Sunday Natural) | €18,90–€89,00 / unit (€0,85–€2,20 / gram NMN) | €75 | 30–90 days (Daily NAD+/Mitophagy) · Quarterly Hit-and-Run (Senolytics) |
| Photobiomodulation & Circadian Lighting Hardware - Sourcing | 04 - Longevity & Environment | Tier 1: Finland Domestic (Innolux / Valoisa / Punainenplaneetta) · Tier 2: EU Single Market | €19,90–€1.199,00 (Hardware) | €0 | 5–10 years (50,000-hr LED Lifespan) |
| Sauna & Cold Plunge Hardware - Sourcing | 04 - Longevity & Environment | Tier 1: Finland Domestic (Harvia / IKI / Narvi / Avantopool / Kirami) | €12,90–€49,00 (Stones & Consumables) · €279–€7.990 (Heaters & Cold Plunges) | €12 | 10–15 years (Kiuas / Plunge) · 12–24 months (Oliviinidiabaasi Kiuaskivet) · 30 days (Plunge Filter & Peroxide) |
| Total Estimated Run-Rate | €678/mo (€8136/yr) |
Templates & Tag Taxonomy
- Templates: Compound Template · Biomarker Template · Protocol Template · Reference Template · Sourcing & Hardware Template
- Primary Tags:
#silo/foundations·#silo/compounds·#silo/diagnostics·#silo/longevity·#silo/sourcing·#silo/references#type/moc·#type/compound·#type/biomarker·#type/protocol·#type/mechanism·#type/sourcing·#type/reference#evidence/tier-1(RCTs / Meta-analyses) ·#evidence/tier-2(Human observational / Mechanistic) ·#evidence/tier-3(Preclinical / Animal / N=1)